Comparative details of the standard and modified hyper cvad 1 or 2 regimens are delineated in table 1 and onlineonly appendix. The recurrence or progression rate was similar for the 2 groups 27% versus 37%, p ns. The md anderson cancer center mdacc study reported a complete. From 19922000, 288 patients received hypercvad at md anderson cancer center. The hyper cvad protocol consists of 4 cycles of part a cycles 1, 3, 5, 7 alternating with 4 cycles of part b cycles 2, 4, 6, 8 for a total of 8. Cd20 positive regardless of the level of expression. Days 11 14 methotrexate 12 mg it day 2 doxorubicin 50 mgm 2 iv day 4 vincristine 2 mg iv in 50 ml of ns day 4, 11. Pdf hypercvad regimen in routine management of adult. If cns is positive at diagnosis, then twice weekly lumbar punctures with intrathecal chemotherapy until negative times two, then per protocol. Department of leukemia, the university of texas md anderson cancer center, 1515 holcombe blvd, unit 428, houston, tx 77030. Eleven patients have been treated so far on our current protocol, 6 of.
Should there be a standard therapy for mantle cell lymphoma. The hypercvad program is one example of a regimen that has been successfully patterned after a previous pediatric regimen and that has developed along. The combination of hypercvad plus nelarabine as frontline therapy in adult tcell acute lymphoblastic leukemia and tlymphoblastic lymphoma. Stem cell transplant sct guidelines are not included with this algorithm. Cvad chemotherapy regimen was first introduced and developed in the md anderson cancer center mdacc 8. The university of texas md anderson cancer center houston, tx sonali smith, m. The hypercvad regimen is a more effective and less toxic salvage regimen for relapsed acute lymphocytic leukemia than highdose aracbased. Acute lymphoblastic leukemia and lymphoblastic page 1 of 8. To evaluate the efficacy and toxicity of hyper cvad fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone, a doseintensive regimen, in adult acute lymphocytic leukemia all. Aim of the study analysis of the efficacy and toxicity results of pediatric dfcp vs. Hyper cvad agents involved cycle a cyclophosphamide 300 mgm 2 iv in 250 ml of ns days 1 3 dexamethasone 40 mg ivpo days 1 4. The hypercvad regimen improves outcome in relapsed acute lymphoblastic leukemia. Study of augmented hypercvad in acute lymphoblastic leukemia. Results of treatment with hypercvad, a doseintensive.